Operil nasal spray for adults 0.05% 10ml

The distribution of this drug over the Internet is strictly prohibited and regulated by the laws of the Republic of Serbia, while its presentation on the Internet is allowed, solely for the purpose of informing the general and professional public about its purpose and better familiarization with the basic characteristics of the drug itself.

YOU CAN VIEW THE REGULATION ON THE METHOD OF ADVERTISING MEDICINE, REGARDING MEDICINE ("Sl. Gl. RS", no. 79/2010) HERE.

Read this manual carefully because it contains information that is important to you.
You can buy this medicine without a doctor's prescription, for the treatment of mild diseases without the help of your doctor. In addition, you need to use this medicine carefully to get the best results from it. If you need any additional information or advice, contact your doctor or pharmacist. If your symptoms worsen or you do not feel better, be sure to see your doctor.

Protected name of the drug, strength of the drug, pharmaceutical form:
Operil 0.05% nasal spray

Unprotected, generic name:
Oxymetazoline

Content of active substances: 
One milliliter of Operil 0.05% nasal spray contains 500mcg/ml of oxymetazoline hydrochloride (0.05% solution).
Content of auxiliary substances:  
One milliliter of Operil 0.05% nasal spray contains: benzolkonium chloride: sodium hydroxide; sodium dihydrogen phosphate, dihydrate; sodium hydrogen phosphate, dihydrate; purified water.

Composition:
One milliliter of Operil 0.05% nasal spray contains 500mcg/ml of oxymetazoline-chiarochloride (0.05% solution).

Pharmaceutical form and content:
nasal spray

What is Operil, nasal spray, 0.05% and what is it for?

• Operil, nasal spray, 0.05% is intended only for adults and children older than 7 years.
• Operil, nasal spray, 0.05% contains oxymetazoline. Oxymetazoline is used as a nasal decongestant. Due to the constriction of arterioles, it reduces the swelling of the nasal mucosa and the runny nose. It establishes freer breathing through the nose and alleviates the accompanying signs and symptoms of the common cold. Operil starts working within a few minutes and its effect lasts 6 to 8 hours.
• Oxymetazoline also has anti-inflammatory and antioxidant effects.
• Operil, nasal spray, 0.05% has an antiviral effect on certain viruses that mainly cause respiratory diseases.

How does Operil, nasal spray, 0.05% work?
Operil, nasal spray, 0.05% works by reducing swelling of the nasal mucosa and nasal discharge. It starts working within a few minutes and its effect lasts for 6 to 8 hours.

When is Operil, nasal spray, 0.05% used?
Operil nasal spray, 0.05% is used for:

• rhinitis due to the common cold
• allergic rhinitis
• rhinosinusitis
• inflammation of the middle ear
• surgery (endoscopic surgery) in the nose to reduce swelling and bleeding

What you must read before using the medicine:
Warn the doctor if you are taking other medicines, have a chronic disease, a metabolic disorder, are hypersensitive to medicines or have had allergic reactions to some of them.

When you must not take the medicine:
You must not use Operil, nasal spray, 0.05%:

• if you know that you are hypersensitive to oxymetazoline or any other ingredient of the medicine
• if you have dry inflammation of the nasal mucosa with scales (atrophic inflammation)

Use Operil, nasal spray, 0.05% with special caution:

• if you are taking, or have taken in the last two weeks, monoamine oxidase inhibitors (MAOIs) (medicines used in the treatment of Parkinson's disease and depression) or other medicines that can lead to an increase in blood pressure
• if you have elevated intraocular pressure, especially angle-closure glaucoma
• if you have severe cardiovascular disease (eg coronary heart disease, hypertension), acute heart disease or asthma caused by heart disease (cardiac asthma)
• if you have a pheochromocytoma of the adrenal medulla)
• if you have porphyria (hereditary blood disease with symptoms of increased sensitivity of the skin to light, the appearance of bleeding scabs on the skin, dark discoloration of the skin, increased lethargy, dark-red discoloration of the urine, sometimes with nerve damage and partial or complete loss)
• if you have had surgery to remove your pituitary gland (pituitary gland)
• if you have metabolic disorders (eg hyperthyroidism, diabetes)
• if you have an enlarged prostate (prostatic hypertrophy)

In all the cases mentioned above, the drug should only be used under the supervision of a doctor.

Warnings and precautions:
Operil should not be used in children younger than 7 years old. Prolonged or excessive use of this drug should be avoided.

Taking Operil, nasal spray, 0.05% with food or drinks:
Operil, nasal spray, 0.05% can be used regardless of meals.

Application in pregnancy and breastfeeding:
Before you start taking any medicine, consult your doctor or pharmacist.
The use of Operil, nasal spray, 0.05% during pregnancy and breastfeeding is not recommended, except on the advice of a doctor. If you become pregnant during therapy, consult your doctor.

Influence on psychophysical abilities when driving a motor vehicle and machines:
Provided that it is used in the recommended doses, Operil®, nasal spray, 0.05% does not affect the ability to drive vehicles and machines.
What you need to know about the excipients contained in the drug Operil, nasal spray, 0.05 %:
Operil contains benzalkonium chloride, which can cause narrowing of the airways (bronchospasm) or skin reactions.

What you need to watch out for if you take other medicines:
Please note that this information may also apply to medicines you are no longer taking, as well as medicines you plan to take in the future. Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
When using other medicines at the same time, it is recommended to consult a doctor or tarmaceut before using Operil nasal spray, 0.05%.
When oxymetazoline is absorbed by oral administration or due to overdose, its effect on blood pressure may be increased in patients taking tricyclic antidepressants or maprotiline at the same time. A hypertensive crisis may even occur in patients taking MAO inhibitors at the same time.

How Operil nasal spray, 0.05% is used:
If you think that the drug Operil, nasal spray, 0.05% has too weak or too strong an effect on your body, consult a doctor or pharmacist.
Adults and children over 7 years of age: one to two sprays of Operil, nasal spray, 0.05% in each nostril two to three times a day; the application of this drug should be performed in accordance with the procedure for using the spray.
When patients are treated with Operil, nasal spray, 0.05% alone, they should not do so for more than five to seven days continuously. If the symptoms do not go away, you should consult a doctor. The doctor can prescribe longer therapy. The nasal spray is intended for one person only. If the same vial is used by several patients, it is likely that there will be a spread of infection.

If you have taken more medicine than you should:
If you have taken a larger dose of Operil, nasal spray, 0.05% than you should, talk to your doctor or pharmacist immediately!
After giving excessive doses, a transient burning sensation in the nose, dry nasal mucosa and sneezing may occur. Insomnia, headache, tachycardia or bradycardia, increase in blood pressure may also occur. These symptoms resolve when the dose is reduced. In case you or your child accidentally swallows this medicine, seek medical advice immediately.

If you forgot to take Operil, nasal spray, solution, 0.05%:
Never take a double dose to make up for a missed dose!
If you forget to give Operil, nasal spray, 0.05% it is recommended to take it as soon as possible without changing the dose or dosing regimen.

What happens if you suddenly stop taking Operil, nasal spray, 0.05% :
No known effects.

Side effects of the drug:
The drug Operil, like other drugs, can have side effects, although they do not necessarily occur in everyone.
The assessment of side effects is based on the following frequency information:

• Very common (more than 1 in 10 treated patients):
• Common (less than 1 in 10 but more than 1 in 100 treated patients)
• Uncommon (less than 1 in 100 but more than 1 in 1000 treated patients)
• Rare (less than 1 in 1000 but more than 1 in 10000 treated patients)
• Very rare (less than 1 in 10,000 patients), frequency not known

Disorders of the heart and blood vessels:
Uncommon: slower heart rate.
Rare: increased heart rate, increased blood pressure, feeling of abnormal heart rate (palpitations)

Nervous system disorders:
Rarely: dizziness, drowsiness, agitation, irritability, sleep disorder in children, insomnia

Respiratory system disorders:
Occasionally: sneezing, dryness and irritation of the nasal mucosa, mouth and throat.
Prolonged use may produce reactive niperemia of the nasal mucosa (medicinal rhinitis).
The frequency is not known.

General disorders:
Rare: transient redness at the site of drug application (reactive hyperemia), headache, nausea, rash and visual disturbances.

Administration of the drug for a longer period of time than recommended may lead to a reduced effect of the drug and/or repeated congestion (nasal congestion).
If any side effect becomes serious or you notice any side effect that is not listed in this guide, please inform your doctor or pharmacist.

Storage:
Keep Operil, nasal spray, 0.05% out of the reach of children. Store the medicine at a temperature of up to 25°C.

Packaging: 10 ml

Procedure for applying the spray:
Correct application reduces the possibility of side effects and improves efficiency.
1. First clean your nose well.
2. Remove the protective cap.
3. Before the first use of a new bottle of medicine, pump a small amount of medicine into the air; pump several times (pushing down) until a fine spray appears.
4. Bend your head forward so that you can see your toes. With your right hand, place the nozzle in the left nostril in the direction of the outer wall of the nose.
5. Press the pump of the bottle down so that the dose is released and inhale through the nose.
6. After that, insert the nozzle with the left hand into the right nostril, direct it towards the outer wall of the nostril, release the dose and inhale through the nose.
7. After use, wipe the nozzle with a clean tissue and replace the protective cap.